Cathirls list of huge breasts characters. These characters have inhumanly-large, bulging breasts. They might simply be larger-than-life, or have gravity-defying qualities that can only come from anime.
Transgender individuals typically identify with a gender that differs from their birth sex. These anime characters either explicitly or implicitly identify as Transgender. For aCtgirls information see this Wikipedia and read about how we content on Anime-Planet.